Search results for " PHTS"
showing 3 items of 3 documents
On the thermal dynamic behaviour of the helium-cooled DEMO fusion reactor
2019
Abstract The EU-DEMO conceptual design is being conducted among research institutions and universities from 26 countries of European Union, Switzerland and Ukraine. Its mission is to realise electricity from nuclear fusion reaction by 2050. As DEMO has been conceived to deliver net electricity to the grid, the choice of the Breeding Blanket (BB) coolant plays a pivotal role in the reactor design having a strong influence on plant operation, safety and maintenance. In particular, due to the pulsed nature of the heat source, the Primary Heat Transfer System (PHTS) becomes a very important actor of the Balance of Plant (BoP) together with the Power Conversion System (PCS). Moreover, aiming to …
Sirolimus treatment of severe PTEN hamartoma tumor syndrome: case report and in vitro studies
2013
Background: Phosphatase and tensin homolog (PTEN) hamartoma tumor syndrome (PHTS) is caused by germ line mutations in the PTEN gene. Symptoms include cancer pre- disposition, immune deviations, and lipomas/lipomatosis. No causal standard therapy is available. We describe a therapeutic attempt with the mammalian target of rapamycin (mTOR) inhibitor sirolimus for a PHTS patient suffering from thymus hyperplasia and lipomatosis. We furthermore assessed the in vitro effects of sirolimus and other inhibitors on lipoma cells of the patient. Methods: The patient underwent clinical and blood examinations and whole-body magnetic resonance imaging to assess tumor sizes. Lipoma cells of the patient we…
Tokamak cooling systems and power conversion system options
2022
DEMO will be a fusion power plant demonstrating the integration into the grid architecture of an electric utility grid. The design of the power conversion chain is of particular importance, as it must adequately account for the specifics of nuclear fusion on the generation side and ensure compatibility with the electric utility grid at all times. One of the special challenges the foreseen pulsed operation, which affects the operation of the entire heat transport chain. This requires a time-dependant analysis of different concept design approaches to ensure proof of reliable operation and efficiency to obtain nuclear licensing. Several architectures of Balance of Plant were conceived and dev…